Metabolites remarkably affected by chronic kidney diseases: Study reveals

Metabolites remarkably affected by chronic kidney diseases: Study reveals

The National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) says that those who suffer from chronic kidney diseases are at the high risk of cardiovascular disease. Not only this, they may initiate the progress of kidney failure. As reported by news medical life science quoted NIDDK, few options still exist to treat these diseases, and the major breakthroughs have been made during the last 30 years. But, it does not mean the risk is any less.

“We analyzed these small molecules in the blood and urine of non-diabetic patients with chronic kidney disease and compared the results to samples obtained from a group of healthy individuals,” said by Stein Hallan, M.D., first author of the study published in EBioMedicine. He said this because there is another study which proved that dozens of small molecules called metabolites are altered in this diseases. This study was done by the University of Washington, the University of California San Diego and The University of Texas Health Science Center at San Antonio.

“Importantly, our study identified that a group of molecules called tri-carboxylic acid (TCA) cycle metabolites are significantly affected in chronic kidney disease.” he further said regarding the study as reported by news medical life science.

“The TCA cycle is a process in which fuel molecules are converted into energy. This activity occurs in mitochondria–the energy centres of all types of cells. The fact that the TCA cycle is significantly impacted in chronic kidney disease supports the view of CKD as a state of mitochondrial dysfunction,” said study senior co-author Kumar Sharma, M.D., FAHA, chief of nephrology and founding director of the Center for Renal Precision Medicine at UT Health San Antonio. This was reported by news medical life science only.

So, the first thing we should do is to treat the kidney diseases because if you leave this untreated it may lead to a chronic disease. Wish you to have a healthy and fit life.

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